Why do disc injuries take so long to heal?

The healing process for a disc injury can be prolonged due to various metabolic factors involved in tissue repair and regeneration. One of the biggest reasons why people with disc injuries relapse is because as they start feeling better, they get over confident and do too much not realising just how long it takes for a disc to properly heal.

While mild strains without tissue disruption can settle in weeks, more serious injuries take months and continue to remodel over a period of up to and beyond 1 year. It’s essential to follow a plan during this time, not just run with how you feel because often cases you can be feeling much better long before the healing is complete.

The metabolic characteristics of intervertebral discs, including their limited blood supply, low metabolic rate, and challenges in nutrient diffusion, as well as factors such as inflammation, cellular senescence, and matrix remodelling, collectively contribute to the protracted healing timeline associated with disc injuries. Understanding these metabolic aspects is essential for developing strategies to promote and expedite the healing process while minimizing the risk of complications and recurrent injuries.

  1. Limited Blood Supply: The intervertebral discs, located between the vertebrae of the spine, have a sparse blood supply compared to other tissues in the body. Blood vessels deliver essential nutrients and oxygen necessary for tissue repair. However, the avascular nature of the discs restricts the availability of these crucial resources, slowing down the healing process.

  2. Low Metabolic Rate: Intervertebral discs have a relatively low metabolic rate compared to other tissues. This means that their cells have a reduced capacity for cellular turnover and repair. The slow metabolism of disc cells contributes to the prolonged duration required for healing and regeneration following an injury.

  3. Nutrient Diffusion: Nutrient diffusion plays a vital role in supplying essential substances, such as oxygen, glucose, and amino acids, to the cells within the disc. However, diffusion rates within the dense extracellular matrix of the disc are relatively slow, particularly in the inner regions where cell density is higher. As a result, the delivery of nutrients to the cells may be insufficient to support rapid healing, leading to a protracted recovery process.

  4. Inflammatory Response: Inflammation is a critical component of the body's healing response to injury. However, excessive or prolonged inflammation can impede the healing process and contribute to chronic pain and tissue damage. In the case of disc injuries, the inflammatory response may be dysregulated, leading to persistent inflammation that interferes with the repair mechanisms and prolongs the healing timeline.

  5. Cellular Senescence: Cellular senescence, the process by which cells enter a state of irreversible growth arrest, can occur in response to various stressors, including injury and inflammation. Senescent cells accumulate in tissues over time and exhibit impaired function, which can hinder the healing process. In the context of disc injuries, the presence of senescent cells within the disc may contribute to delayed repair and regeneration.

  6. Matrix Remodelling: The extracellular matrix of the intervertebral disc undergoes remodelling during the healing process to restore its structural integrity and biomechanical properties. However, matrix remodelling is a complex and time-consuming process that involves the synthesis, deposition, and organization of new matrix components. The gradual nature of matrix remodelling contributes to the extended duration required for complete healing of the injured disc.

So of all the injuries we manage in the practice, disc injuries are often the ones that require the most patience and commitment. Now that we have covered TIME, in the next blog we are going to talk about the other factors that contribute to the recurrence of disc injuries.

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